Projects / Bulgarian
Projects funded by Medical University - Sofia
| Project Title | Year | Principal Investigator (PI)/Co-Principal Investigator (coPI) | Organisation |
| Studying the role of SKAP2, SUMF1, CROCC and TNS1 aberrations in the pathology of inborn kidney and urinary system anomalies | 2013-2014 | Assoc. Prof. A. Bueva, MD, PhD | Clinic of Paediatric Nephrology, MU - Sofia |
| Clonal descendance of mulptiple resistance invasive and respiratory strains of Streptococcus pneumoniae isolated before and after the introduction of mass immunization with Pneumococcus conjugate vaccine (2006-2013). | 2013-2014 | Assoc. Prof. Rumyana Markovska, PhD, MD | Department of medical microbiology, MU - Sofia |
| Molecular defects in benign neonatal forms of epilepsy and clinical electrophysiological syndromes | 2013-2014 | Assoc. Prof. A. Jordanova, PhD | MU-Sofia |
| Expression analysis of miRNAs 146 and 155 in blood and synovial fluid of rheumatoid arthritis and osteoarthrosis patients and determination of their diagnostic and prognostic value | 2013-2014 | Prof. Zlatimir Kolarov, PhD, MD | University Hospital Sv. Ivan Rilski |
| Studying the role of RELN, COL1A1 and BMP2 polymorphisms in the pathogenesis of otosclerosis | 2013-2014 | Prof Diana Popova, PhD, MD | MU-Sofia |
| Expression of the fusion oncogene EML4-ALK in Bulgarian patients with non-small cell lung carcinoma | 2013-2014 | Assoc. Prof. Yanina Slavova-Marinova, PhD, MD | Specialized lung disease hospital „St. Sofia” |
| Molecular genetic analysis of genes with medium penetrance in BRCA negative patients with familial breast carcinoma | 2013-2014 | Assoc. Prof. S. Hristova, PhD, MD | University Hospital Aleksandrovska |
| Analysis of polymorphisms in candidate genes associated with arterial hypertonia in Bulgarian patients | 2013-2014 | Assoc. Prof. Kiril Naydenov, PhD | MU-Sofia |
| Study of the genetic determinants of neurocognitive endophenotypes in dependencies | 2013-2014 | Assoc. Prof. Radka Kaneva, PhD | MU-Sofia |
| Expression analysis of SOX2, SOX6, SOX8, and SOX9 and their applicability as prognostic markers in malignant glial tumours | 2013-2014 | Prof. N. Gabrovsky, MD, PhD | University Hospital "Pirogov" |
| Association study of candidate genes CACNA1C and ANK3 in Bulgarian patients with Bipolar Affective disorder | 2012-2013 | Prof. V. Milanova, MD, PhD | University Hospital Aleksandrovska |
| Study of the molecular basis of hereditary spastic paraplegy with autosomous recessive inheritance through clinical and genetic analysis of patients from Roma population | 2012-2013 | Assoc. Prof. A. Jordanova, PhD | MU-Sofia |
| Genotype- phenotype correlations in neurodegenerative disorders, characterized with parkinsonism | 2012-2013 | Prof. L. Traykov, MD, PhD | Department of Neurology, University Hospital Aleksandrovska |
| Pilot study of the role of RELN gene in the pathogenesis of otosclerosis | 2012-2013 | Assoc. Prof. D. Popova, MD, PhD | Department of otolaryngology, MU - Sofia |
| Introducing a mutational screening for trascription factors POU1F1 (PIT1), HESX1, SOX3 in patients with congenital hyposomatotropism | 2012-2013 | Assoc. Prof. I. Stoeva, MD, PhD | Clinic of Paediatric diseases, MU - Sofia |
| Study of the role of genomic aberrations, deletions and duplications in the pathology of congenital anomalies of the kidney and urinary tract (CAKUT) | 2011-2012 | Assoc. Prof. A. Bueva, MD, PhD | Clinic of Paediatric Nephrology, MU - Sofia |
| Association study of candidate genes and endophenotypes in patients with Bipolar Affective disorder | 2011-2012 | Prof. V. Milanova, MD, PhD | University Hospital Aleksandrovska |
| Study of mutations in HFE gene in patients with chronic liver diseases with or without iron overload syndrome | 2011-2012 | Prof. L. Vladimirova, MD, PhD | University Hospital Sv. Ivan Rilski |
| Analysis of mutations in BRCA1 gene in Bulgarian patients with triple negative breast cancer | 2011-2012 | Assoc. Prof. S. Hristova, MD, PhD | University Hospital Aleksandrovska |
| Early cognitive impairments in patients with arterial hypertonia | 2011-2012 | Assoc. Prof. K. Naidenov, MD, PhD | MU-Sofia |
| Molecular genetic analysis of CDKL5 and PCDH19 genes in girls with epylepsy | 2011-2012 | Prof. P. Dimova, MD, PhD | MU-Sofia |
| Molecular characteristics of familial amyloid polyneuropathy in Bulgaria | 2011-2012 | Prof. I. Tarnev, MD, PhD | MU-Sofia |
| Enhancing the capacity of the cores Cell and Tissue Cultures, Microarray and Laser Microdissection in Molecular Medicine Center, MU - Sofia, infrastructural project | 2010-2011 | Prof. V. Mitev, MD, PhD | MU-Sofia |
| Study of the molecular basis of congenital anomalies of the kidney and urinary tract (CAKUT) in Bulgaria. Role of Pax2 for the pathogenesis of CAKUT | 2010-2011 | Assoc. Prof. A. Bueva, MD, PhD | Clinic of Paediatric Nephrology, MU - Sofia |
| Analysis of promoter hypermethylation of biomarkers in urine of patients with prostate cancer - validation of their diagnostic value in Bulgarian population | 2010-2011 | Prof. Ch. Slavov, MD, PhD | MU-Sofia |
| Genetic, neuropsychological and vascular markers for early detection of Alzheimers Disease | 2009-2010 | Prof. L. Traykov, MD, PhD | Department of Neurology, University Hospital Aleksandrovska |
| Study of candidate genes in linkage region for partial epilepsy | 2009-2010 | T. Goranova, PhD | MMC, MU-Sofia |
| Analysis of big deletions, insertions and rearrangements in BRCA1 and BRCA2 | 2009-2010 | Assist. Prof. A. Mitkova, PhD | MMC, Department of Medical Chemistry and Biochemistry, MU-Sofia |
| Analysis of polymorphic variants in candidate genes associated with prostate cancer | 2009-2010 | Assist. Prof. R. Kaneva, PhD | MMC, Department of Medical Chemistry and Biochemistry, MU-Sofia |
| Study of the role of hepatocyte nuclear factor 1-beta (HNF1b) for the development of congenital anomalies of the kidney and urinary tract | 2009-2010 | Assist. Prof. O. Beltcheva, PhD | MMC, Department of Medical Chemistry and Biochemistry, MU-Sofia |
| Molecular diagnostic of deafness | 2009-2010 | Prof. K. Kunev, MD, PhD | University Hospital Tzaritza Yoanna |
| Squamous cell carcinoma of the larynx and the hypopharynx. Genetic defects associated with carcinogenesis and biological behaviour of the tumor | 2009-2010 | Assoc. Prof. I. Chalakov, MD, PhD | University Hospital Tzaritza Yoanna |
| Phenotypic characteristics of idetached population | 2009-2010 | Assist. Prof. A. Kancheva-Beleva | University Hospital Aleksandrovska |
| Familial associative analysis of neurocognitive disorders and DISC1 gene in bipolar affective disorder patients | 2009-2010 | Prof. V. Milanova, MD, PhD | University Hospital Aleksandrovska |
| Study of relationship between polymorphic variants in interleukin 10 (IL10) and the dermatomiosit origin in Bulgaria | 2009-2010 | Chief Assist. Prof. L. Durmishev, MD | University Hospital Aleksandrovska |
| Evaluation of the relevance of the beta-catenin (CTNNB1) gene mutation analysis for patients with endometrial cancer | 2008-2009 | Prof. V. Mitev, MD, PhD | MU-Sofia |
| Study of the role of the polymorphisms in tumor necrosis factor- alfa (TNF-α) for dermatomyosit pathology in Bulgaria | 2008-2009 | Assis. Prof. L. Durmishev, MD | Dermatology and Venerology Department, University Hospital Aleksandrovska |
| Influence of genetic variants in ABCA4 gene on development of age-related macula degeneration (ARMD) and assessment of the risk for disease on Bulgarian population | 2008-2009 | Prof. I. Kremensky, MD, PhD | MMC, MU-Sofia |
| Frequency and characteristics of the WT1 gene mutations in patients with steroid-resistant nephrotic syndrome | 2008-2009 | O. Beltcheva, PhD | MMC, MU-Sofia |
| Analysis of big genome deletions, insertions and rearrangements in MLH1 and MLH2 genes in Bulgarian patients with colorectal cancer | 2008-2009 | Senior Assist. Prof. R. Kaneva, PhD | MMC, Department of Medical Chemistry and Biochemistry, MU-Sofia |
| Study of the role of polymorphic variants in metabotropic glutamate receptor 1 for predisposition to affective disorders and narcotic dependences | 2007-2008 | Prof. I. Kremensky, MD, PhD | MMC, MU-Sofia |
| Role of the podocin gene (NPHS2) mutations for the pathology of steroid-resistant nephrotic syndrome and microalbuminuria population risk in Bulgaria | 2007-2008 | O. Beltcheva, PhD | MMC, MU-Sofia |
| Mutations in BRCA1 and BRCA2 cancer susceptible genes and their association with the development of breast and prostate cancer in Bulgaria | 2007-2008 | A. Mitkova, PhD | MMC, MU-Sofia |
| Researching of genetic markers for determinating possibility of development of aerobic and anaerobic quality in sportsman who have active competitive sporting activity | 2007-2008 | Assoc. Prof. P. Atanasov, PI, S. Andonova, R. Saraeva and R. Kaneva - coPIs | National Sports Academy and Molecular Medicine Center, Medical University-Sofia |
| Endophenotipic characteristics of ill persons with Affective disorders | 2007-2008 | V. Milanova, MD | Psychiatry Department, Medical University-Sofia |
| Investigation of the level of informativeness about Hereditary Colorectal Carcinoma between group of doctors and patients | 2007-2008 | Prof. D. Damianov, MD, PhD | University Hospital Tzaritza Yoanna |
| Study on the Role of Polymorphisms in Genes XRCC1 and XRCC3 for Development of Early Radiation Reactions after Radiation Therapy of Cervical and Endometrial Carcinomas | 2006-2007 | A. Savov, PhD | NGL, University Hospital of Obstetrics and Gynaecology Maichin Dom |
| Frequency of primary alosterism between patients with proven hypertonia | 2005-2006 | J. Matrozova, MD | University Hospital of Endocrinology and Gerontology Acad. I. Penchev |
| Role of matriptase and its inhibitor (HAI1) in development and progression of malignant skin tumors | 2004-2005 | J. Bocheva, MD; A. Jordanova, PhD | Pharmacology Department, Medical University-Sofia |
| Investigation of anti-integrative action of 4-hydroxycoumarine derivates that have showed anti-HIV activity | 2004-2005 | S. Raleva, MD; A. Jordanova, PhD | National Centre of Infectious and Parasitic Diseases |
| Fine mapping of locus 4p16 linked with bipolar affective disorder in Bulgarian families | 2004-2005 | R. Kaneva, PhD | NGL, University Hospital of Obstetrics and Gynaecology Maichin Dom |
| Study of clinical and pathomorphological features of hereditary and sporadic colorectal carcinoma | 2002-2003 | Prof. D. Damianov, A. Savov, PhD, T. Kadiyska | Department of Surgery, University Hospital Tzaritza Yoanna and National Genetics Laboratory |
| Analysis for linkage of chromosome 21q22 in patients with Bipolar affective disorder from Bulgarian families | 2001-2002 | R. Kaneva, PhD | NGL, University Hospital of Obstetrics and Gynaecology Maichin Dom |
