Projects / Bulgarian


PhD Students Projects

Project Title  Year Principal Investigator (PI)/Co-Principal Investigator (coPI) Organisation
Expression analysis of molecular markers in circulating tumour cells (CTC) from peripheral blood in Bulgarian patients with metastasized breast carcinoma 2013-2014 Daniela Dacheva (MSc),
PhD student
Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Expression profiling of miRNAs in blood plasma and urine of prostate cancer patients 2013-2014 D. Kachakova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Connection between neurocognitive disruptions in patients with BAR type-1 and genetic polymorphisms in DISC1 2013-2014 Mladen Penchev (MD), PhD student Department Psychiatry, MU-Sofia
Genetic aspects of the non-syndromic loss of hearing - Connexin 26, 30, and 31 2013-2014 Iglika Stancheva (MD), PhD student Department of ORL, University Hospital "Tzaritza Yoanna", MU-Sofia
Association study of polymorphic variants in leading candidate - genes from GWAS in patients with coronary artery disease in Bulgarian population 2013-2014 R. Tzveova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Molecular and genetic factors in angiogenesis of laryngeal squamous cell carcinoma 2013-2014 T. Popov, MD, PhD student Department of ORL, University Hospital "Tzaritza Yoanna", MU-Sofia
Mutation screening of LRRK2 in Bulgarian patients with Parkinson`s Disease 2013-2014 Kalina Mihova (MSc),
PhD student
Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Methodology of isolation and keeping of tumour tissues for the detection of prognostic and predictive factors in mammary gland carcinoma 2013-2014 Mariela Vasileva (MD), PhD student Department of Surgery, -
Introducing a mutational analysis of SOX2 in Bulgarian patients with congenital hyposomatotropism and/ or vision anomalies 2012-2013 A. Aroyu, MD, PhD student Department of Pediatry, MU - Sofia
Genetic aspects of nonsyndromic deafness - connexin 26 and 30 2012-2013 I. Stancheva, MD, PhD student Department of ORL, University Hospital "Tzaritza Yoanna", MU-Sofia
Expression levels of miRNAs in blood and synovial fluid as potential biomarkers for diagnostics and prognosis in rheumatoid arthritis 2012-2013 R. Shumnalieva, MD, PhD student Department of Internal Medicine, MU - Sofia
Molecular and genetic basis of angiogenesis in squamous cell carcinoma of the larynx 2012-2013 T. Popov, MD, PhD student Department of ORL, University Hospital "Tzaritza Yoanna", MU-Sofia
Expression profiling of miRNAs in prostate tissues and plasma of Bulgarian prostate cancer patients  2012-2013 D. Kachakova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Impact of genetic factors on the therapy with indirect anticoagulants of Bulgarian patients with cardiovascular diseases 2012-2013 R. Tzveova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Analysis of large genomic deletions, insertions and rearrangements in  BRCA1 and BRCA2 genes in Bulgarian patients with triple negative breast cancer 2012-2013 R. Dodova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Expression analysis of CAIX, MMP-9 and TGF-β2 genes and their application as prognostic markers in malignant glial tumours 2012-2013 G. Stancheva (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Promoter hypermethylation in laryngeal carcinogenesis 2011-2012 S. Jordanov, MD, PhD student Department of ORL, University Hospital "Tzaritza Yoanna", MU-Sofia
Genetic analysis of mutations in exon 11 of BRCA2 gene in Bulgarian patients with hereditary breast cancer  2011-2012 R. Dodova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Association study of candidate genes for suicidal behaviour in patients with various psychiatric disorders  2011-2012 Turan Asan, MD,
PhD student
Department of Psychiatry, MU - Sofia
Analysis of mutations in IDH1, IDH2 and TP53 genes and 1p/19q deletions in Bulgarian patients with malignant glial tumours 2011-2012 G. Stancheva (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Molecular genetic analysis of SLC2A1 gene and phenotype-genotype correlations in patients with absanse epilepsy of early development 2011-2012 D. Kancheva (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Association study of polymorphic variants in locus 1115 and their role in prostate carcinogenesis  2011-2012 D. Kachakova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Analysis of polymorphisms in low-penetrance genes associated with high risk of breast cancer  2010-2011 R. Dodova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Genetic markers with prognostic value in high-grade gliomas  2010-2011 G. Stancheva (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
Determination of mutation frequencies in  MSH6 gene between patients with endometrial carcinoma which biopsycal materials show inactivating mutations in KRAS gene 2009-2010   D. Konstantinova (MSc), PhD student Molecular Medicine Center, Department of Medical Chemistry and Biochemistry,  MU-Sofia
 Association study of polymorphic variants in regulatory genes of androgen biosynthesis (CYP1B1, CYP19 SRD5A2) with increased risk for development of prostate cancer in Bulgaria 2008-2009 E. Popov, MD, PhD Student University Hospital "Aleksandrovska", Department of Urology 
Molecular-genetic analysis of  SCN1A gene and phenotype- genotype correlations in patients with generalized epilepsy with febrile seizures plus (GEFS+) 2007-2008 I. Jordanova (MSc), PhD student Department of Obstetrics and Gynaecology, Medical Faculty, Medical University-Sofia
Association study of the role of I157T polymorphism in CHEK2 gene for developing of colorectal and endometrial carcinoma in Bulgarian patients  2007-2008 D. Konstantinova (MSc), PhD student Medical Chemistry and Biochemistry Department, Medical Faculty, Medical University-Sofia
Prognostic value of timidilat synthase expression in patients with colorectal carcinoma 2006-2007 N. Nedialkov , MD, PhD student Department of Internal Medicine, Gastroenterology Clinics, University Hospital "Tzaritza Yoanna", MU-Sofia
Study of genetic polymorphisms  4G/5G in promoter regions of  PAI-1 gene and   PIA1/PIA2 from gene, coding  IIIa subunit of  IIb/IIIa glycoprotein receptor in patients with miocardial infarction and healthy controls in Bulgarian population 2006-2007 A. Nosilkov , MD, PhD student Laboratory of Immunology, Allergology Clinics, Medical Faculty, Medical University-Sofia
Study of clinical molecular and genetic characteristics of nonpoliposis colorectal cancer in Bulgarian population  2005-2006 E. Kostadinov , MD, PhD student Gastroenterology Clinics, University Hospital "Tzaritza Yoanna", MU-Sofia
550delA CAPN3 mutation in Bulgarian patients with  LGMD2A 2003-2004 B. Georgieva (MSc), PhD student National Genetics Laboratory, University Hospital ``Maichin Dom``
Researching promoter hypermethylation of  MLH1 and MSH2 genes in connection of microsatellite instability in colorectal carcinoma  2001-2002 T. Kadiyska (MSc), PhD student Medical Chemistry and Biochemistry Department, MF, MU-Sofia