За нас / Ръководство


Акад. Проф. д-р Ваньо Митев, дбн


E-mail: mitev@medfac.acad.bg



Образование:


1998     професор - Кат. Химия и Биохимия, МУ-София

1997     доктор на науките - Кат. Химия и Биохимия, МУ-София

1995     доцент - Кат. Химия и Биохимия, МУ-София

1987     доктор по медицина - Кат. Химия и Биохимия, МУ-София

1982     магистър по медицина - Медицинска академия, София, Медицински факултет



Заемани длъжности:


2008 -           Ректор на МУ-София

2003-2008   Началник отдел международна интеграция и политика, МУ-София

1999-2003   Зам. Декан по наука, Медицински факултет, МУ-София

1999            Ръководител катедра - Кат. Химия и Биохимия МУ-София

1999            Ръководител секция - Кат. Химия и Биохимия МУ- София



Чужди езици:


Английски, френски, руски



Области на професионален интерес:


Протеин кинази, кератиноцити, пролиферация, диференциация, апоптоза, биоактивни вещества



Участие в проекти:


Ръководител-


2009-2013        Национален Университетски Комплекс за Биомедицински и Приложни Изследвания, инфраструктурен проект, ФНИ, МОН

2009-2010        Доизграждане на звена Клетъчни и Тъканни Култури и Микрочипове и Лазерна Микродисекция към ЦММ, МУ - София, инфраструктурен проект, МУ-София, 8I-2009

2008-2009        Оценка на анализа за мутации в гена за бета-катенин (CTNNB1) при пациенти с ендометриален карцином


Участник-


2010-2011        Изследване на молекулните основи на вродените аномалии на бъбреците и отделителната система (ВАБОС) в България. Роля на Pax2 за патогенезата на ВАБОС

2010-2011        Изследване на промоторно хиперметилиране на биомакери в урина, асоциирани с рака на простатата и оценяване на тяхната диагностична стойност при български пациенти

2009-2012         Съвременни подходи за разкриване генетичните основи на епилепсията

2009-2012         Клинични и молекулни маркери с прогностична стойност за преживяемостта, качеството на живот и ефекта от лечението при малигнени глиални тумори

2009-2010         Анализ за големи делеции, инсерции и пренареждания в  BRCA1 и BRCA2

2009-2010        Анализ на полиморфни варианти в кандидат-гени асоциирани с рака на простатата 



Публикации:


1.        Todorov T, Todorova A, Georgieva B, Mitev V. A unified rapid PCR method fordetection of normal and expanded trinucleotide alleles of CAG repeats in huntington chorea and CGG repeats in fragile X syndrome. Mol Biotechnol. 2010 Jun;45(2):150-4.

2.        Guenova E, Volz T, Eichner M, Hoetzenecker W, Caroli U, Griesinger G, Burow G, Mitev V, Biedermann T. Basal serum tryptase as risk assessment for severe Hymenoptera sting reactions in elderly. Allergy. 2010 Feb 1. [Epub ahead of print]

3.        Poumay Y, Mitev V. Members of the EGF receptor family in normal and pathological epidermis. Folia Med ( Plovdiv ). 2009 Jul-Sep;51(3):5-17. Review.

4.        Kirilov G, Zacharieva S, Alexandrov AS , Lozanov V, Mitev V. Increased plasma endothelin level as an endothelial marker of cardiovascular risk in patients with active acromegaly: a comparison with plasma homocysteine. Methods Find Exp Clin Pharmacol. 2009 Sep;31(7):457-61.

5.        Konstantinova D, Kaneva R, Dimitrov R, Savov A, Ivanov S, Dyankova T, Kremensky I, Mitev V. Rare mutations in the PIK3CA gene contribute to aggressive endometrial cancer. DNA Cell Biol. 2010 Feb;29(2):65-70.

6.        Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, HopperJL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL,Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY,Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, OBrien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC,Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL,Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM,Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J,Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A,Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium, Easton DF. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct;41(10):1116-21. Epub 2009 Sep 20.

7.        Benkova B, Lozanov V, Ivanov IP, Mitev V. Evaluation of recombinant caspase specificity by competitive substrates. Anal Biochem. 2009 Nov 1;394(1):68-74. Epub 2009 Aug 3.

8.        Konstantinova DV, Kadiyska TK, Kaneva RP, Tosheva EG, Guseva VT, Dimitrov BH, Dimitrov RG, Doganov NI, Ivanov SI, Kremensky IM, Mitev VI. CHEK2 I157T and endometrial cancer. DNA Cell Biol. 2009 Jan;28(1):9-12. PubMed PMID: 18834326.

9.        Kirilov, G., Zacharieva, S., Alexandrov, A.S., Lozanov, V., Mitev, V., 2009, Increased plasma endothelin level as an endothelial marker of cardiovascular risk in patients with active acromegaly: A comparison with plasma homocysteine, Methods and Findings in Experimental and Clinical Pharmacology 31 (7), pp. 457-461

10.     Benkova, B., Lozanov, V., Ivanov, I.P., Mitev, V., 2009, Evaluation of recombinant caspase specificity by competitive substrates,Analytical Biochemistry 394 (1), pp. 68-74  

11.        Benkova, B., Lozanov, V., Ivanov, I.P., Kalenderova, S., Stoev, G., Yordanova, N., Milchova, M., Mitev, V., 2009, Quantitation of the homocysteine content in wine, European Food Research and Technology 230 (2), pp. 361-365

12.       Isaeva AR , Mitev VI (2009).Inhibition of protein kinase CK2 induces E2F1 nuclear export, formation of p21/E2F1 complexes and suppression of DNA synthesis in normal human epidermal keratinocytes. J Dermatol Sci., April 29

13.      Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev V.,2009,  Investigation on the influence of certain additives to the electrode solutions for improvement of isoelectric focusing, Comptes Rendus de LAcademie Bulgare des Sciences 62 (9), pp. 1095-1102

14.      Mateva, L., Petrov, S., Elenkova, A., Zacharieva, S., Mitev V., 2009, Plasma and urinary catecholamines and metanephrines in the diagnosis of autonomic disorders, Comptes Rendus de LAcademie Bulgare des Sciences 62 (7), pp. 905-912

15.      Naydenov, C.L., Kirazov, E.P., Lozanov, V.S., Kirazov, L.P., Mitev, V.I., 2008, Electrochemical reactions during isoelectric focusing and their role in establishment of the pH gradient, Chromatographia 69 (9-10), pp. 887-895

16.      Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev, V., 2008,  Electrochemical explanation of the pH gradient drifts during isoelectric focusing, Comptes Rendus de LAcademie Bulgare des Sciences 61 (12), pp. 1561-1566

17.      Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev, V., 2008, Instabilities of the pH gradient during isoelectric focusing and their relationship with the electrochemical reactions occurring in the electrode solutions, Comptes Rendus de LAcademie Bulgare des Sciences 61 (7), pp. 899-904

18.      Todorova, A., Guergueltcheva, V., Genova, J., Mihaylova, V., Todorov, T., Tchamova, T., Georgieva, B., (...), Mitev, V., 2009, Molecular diagnostics of duchenne/becker muscular dystrophy patients by multiplex ligation-dependent probe amplification analysis and direct sequencing, Balkan Journal of Medical Genetics 12 (2), pp. 3-9

19.      Naydenov, C., Kirazov, E., Lozanov, V., Kirazov, L., Mitev V., 2009, A criterion for the drive of the isoelectrofocusing system toward steady state, Comptes Rendus de LAcademie Bulgare des Sciences 62 (1), pp. 41-48

20.      Guenova E, Weber HO, Voykov B, Metzler G, Mitev V, Berneburg M, Hoetzenecker W, Röcken M. (2008) Palmar-plantar erythrodysesthesia secondary to sunitinib treatment resulting in necrotic foot syndrome aggravated by background diabetic vascular disease. Arch Dermatol., 144(8):1081-2

21.   Todorova A, Todorov T, Georgieva B, Lukova M, Guergueltcheva V, Kremensky I, Mitev V. (2008) MLPA analysis/complete sequencing of the DMD gene in a group of Bulgarian Duchenne/Becker muscular dystrophy patients.Neuromuscul Disord.,Aug;18(8):667-70.

22.    Ivanova P, Atanasova G, Poumay Y, Mitev V. (2008) Knockdown of PKD1 in normal human epidermal keratinocytes increases mRNA expression of keratin 10 and involucrin: early markers of keratinocyte differentiation. Arch Dermatol Res., Mar;300(3):139-45.

23.     Atanasova G, Isaeva A, Ivanova P, Kalenderova S, Poumay Y, V. Mitev. Pharmacological growth inhibition of papillomavirus type 16 E6E7-transformed keratinocytes by CDK-inhibitor CYC202. Comp Rend Acad Bulg Sci 60, №4, 2007, 183-189

24.    Atanasova G, Isaeva A, Zhelev N, Poumay Y, V Mitev. Effect of the CDK-inhibitor CYC202 on p38MAPK, ERK ½, c-Myc activities and proliferation of papillomavirus type 16 E6E7-transformed keratinocytes. Oncology Reports 18, (4) 2007, 999-1005.

25.    Atanasova G, Ivanova P, V Mitev. Mitogenic stimulation with Epidermal Growth Factor, Amphiregulin and Heregulin has distinct effect on the kinetics of ERK activation in autocrine culture of normal human keratinocytes. Comp Rend Acad Bulg Sci